Role of intestinal microbiota in alcohol use disorder

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The field of the microbiota-gut-brain axis is gaining growing interest in relation to several brain disorders, including (alcohol use disorder (AUD). Despite this disorder being traditionally considered a pure brain illness, a number of studies support the involvement of the gut microbiota in its onset/development. However, the direction and potential causality of the link microbiota-brain are not well understood to date. The aim of our project is to evaluate the microbiota as a potential biomarker of alcohol addiction, which will open up the possibility, in the long term, of establishing an innovative and easily modifiable target in the management of alcohol dependence.

This project is developed with the collaboration of several teams, including several clinical departments involved in the recruitment of patients.

MOODS: CESP – Laboratory of Neuropharmacology – Preclinic Unit/ Université Paris-Saclay

GRAP: Group of research on alcohol and pharmaco dependence, Université d’Amiens

UMR1144: Optimisation thérapeutique en Neuropsychopharmacologie. Mecanismes de toxicité et optimisation thérapeutique des psychotrope. Université Paris Cité

Ciocan D, Cassard AM, Becquemont L, Verstuyft C, Voican CS, El Asmar K, Colle R, David D, Trabado S, Feve B, Chanson P, Perlemuter G, Corruble E. Blood microbiota and metabolomic signature of major depression before and after antidepressant treatment: a prospective case-control study. J. Psychiatry and Neuroscience. 2021 May 19;46(3):E358-E368. doi: 10.1503/jpn.200159